A study of predictors & prevalence of neurodevelopmental outcome in hyper-bilirubinemic neonates admitted in NICU

---

Original Article

Author Details : Monika Sharma, Ghanshyam Singh Sengar, Niranjan Nagaraj, Shikha Khandelwal, Vikram Yadav

Volume : 2, Issue : 4, Year : 2016

Article Page : 108-112

Suggest article by email

Get Permission

---

Abstract

Background: Hyper-bilirubinemia may be toxic to the developing central nervous system and may cause neurological impairment. This study was conducted to identify factors of abnormal neurodevelopment at 3 & 12 months in babies having birth weight >1.5 kg and gestational age >34 weeks with neonatal hyper-bilirubinemia.
Methods: This prospective study was conducted at Sardar Patel Medical College, Bikaner (Rajasthan) from 2014 to 2015. Hyper-bilirubinemic newborns were examined at 3 and 12 month age and their neurodevelopmental assessment was done by DASII method. All the collected data was tabulated and statically analyzed by using SPSS software.
Results: 69.79% of hyper-bilirubinemic neonates were males & 30.21% were females. The prevalence of neurodevelopmental abnormalities (DQ?70) was 10.42% at 3 months where as it was 6.25% at 12 months follow up suggesting reversibility of adverse neurodevelopment. Early onset of jaundice (?1 day), serum bilirubin level >25 mg/dl, duration of hospital stay>3 days and requirement of exchange transfusion was significantly associated with adverse neurodevelopmental outcomes (DQ?70) at 3 and 12 months of age on follow up. 
Conclusion: This Prospective observational study found a high prevalence of adverse neurodevelopmental outcome in neonates with hyper-bilirubinemia with risk factors. Early detection of neurodevelopmental abnormalities and initiation of early intervention measures to reduce the prevalence of neurodevelopmental abnormalities in hyper-bilirubinemic neonates.

Keywords: Hyper-bilirubinemia, Neurodevelopemental, Follow up, DASII, Bikaner

How to cite : Sharma M, Sengar G S, Nagaraj N, Khandelwal S, Yadav V, A study of predictors & prevalence of neurodevelopmental outcome in hyper-bilirubinemic neonates admitted in NICU. IP Indian J Neurosci 2016;2(4):108-112

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.