Microelectrode recordings (MER) signals with subthalami nucleus (STN) deep brain stimulation (DBS) local field potentials (LFP) in basal ganglion circuitry in Parkinsonians

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Original Article

Author Details : Venkateshwarla Rama Raju*

Volume : 9, Issue : 1, Year : 2023

Article Page : 14-18

https://doi.org/10.18231/j.ijn.2023.003

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Abstract

Since last 10 years, the authors have established what seems designate a extremely effective phenomenological model-prototype for evaluating the D B S in alleviating symptoms of Parkinson disease (PD). In this study, we broaden the scope of the model applying it to predict the computation and then generating more frequencies as of net-works (NW) tuned to a particular frequency, in fact not an self - oscillatory in any way. Two main issues discussed, 1. basic and fundamental systems are connected (or coupled) in an excitatory vogue, that is designated by ‘+ / +’, 2. Where the basic/constituent systems are connected in excitatory-inhibitory way, designated by ‘+ / -’. It expects that as of a ‘basic-system’ tuned-to tremor-frequency such that we can compute/ generate infinite (limitless) range-of-frequencies. Our example specifically, start as of systems that are primarily non oscillatory, which while the connecting coefficient surpasses a certain/threshold-value, the system starts to oscillate by the signal-amplitude that enhances through he connecting/‘coupling-strength’. One more feature-manifestation, that shown to rise by connecting complex net-works based on physiology of basal-ganglia(BG) be exemplified through “root-locus” strategy method that displays enhancing plus reducing oscillatory frequencies, present concurrently, has the theory which their symmetrical average-mean leftovers/remnants significantly continuous as the connecting-strength(amplitude) is speckled. Through this method, we are offering a new utility-tool to comprehend reality also interface of “pathological-oscillations” that trigger, PD plus more ailments ex. Memory, cognition, cognitive-impairment (CI), cognitive dementia (CD), depression, epileptic-seizures, Tourette’s syndrome, Huntington’s disease, and axial symptoms like speech, hallucinations, and gait.
 

Keywords: Computational simulation prototype models, Systems and control­theory, Parkinson disease, Oscillatory­frequencies, Pathological oscillations

How to cite : Raju V R, Microelectrode recordings (MER) signals with subthalami nucleus (STN) deep brain stimulation (DBS) local field potentials (LFP) in basal ganglion circuitry in Parkinsonians. IP Indian J Neurosci 2023;9(1):14-18

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