Induced micro lesion effect on cardinal motor features of Parkinson‘s: A study with iMER signals of subthalamic-nuclei deep brain stimulations (Electrode-Implantation) by DBS

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Original Article

Author Details : Venkateshwarla Rama Raju*, Srinivas Konda, Kavitha Rani Balmuri, Anvesh Balabhadra

Volume : 6, Issue : 3, Year : 2020

Article Page : 220-225

https://doi.org/10.18231/j.ijn.2020.042

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Abstract

Induced micro lesion effect ( mLE) on basic motor symptoms of Parkinson‘s showing good results with the intra operative micro electrode recordings (iMER) of subthalamic-nuclei (STN) signals (patterns or signatures of STN) all through deep brain stimulations (DBS). MER-induced mLE was computed based on the difference between tremor, rigidity, and Bradykinesia (akinesia) scores in the pre op off-state and intra op on state following MER prior to test stimulus. To study the induced micro lesion effect on cardinal motoric feature-manifestations (symptoms) of Parkinson‘s during the subthalamic nuclei deep brain stimulations by the intra operative microelectrode recordings. Clinical Relevance — stimulated intra operative microelectrode recordings micro lesion effect progressed the motor-manifestations of Parkinson‘s. However, uncorrelated by the electrodes employed for the period of the process. MER-induced mLE was computed based on the difference between tremor, akinesia/Bradykinesia, and rigidity scores in the pre operative OFF state and intra operative state prior to stimulus-test experiment subsequent with micro
electrode recording The MLE scores were enhanced by circa ~ 22% on Brains left hemisphere (BLH) and by ~14% on Brains right hemisphere (BRH) from zero line, i.e., electrical base line (p<0>0.05). Stimulated intra operative microelectrode recordings and mLE progressed the motor-manifestations of Parkinson‘s, yet, uncorrelated by the electrodes employed for the period of process.

Keywords: Deep brain stimulation (DBS), Micro electrode recording (MER), Micro lesion effect (MLE), Parkinson?s disease (PD), Sub thalamic nuclei (STN).

How to cite : Raju V R, Konda S, Balmuri K R, Balabhadra A, Induced micro lesion effect on cardinal motor features of Parkinson‘s: A study with iMER signals of subthalamic-nuclei deep brain stimulations (Electrode-Implantation) by DBS. IP Indian J Neurosci 2020;6(3):220-225

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