Relationship of Serum Vitamin D levels with Nerve Conduction Velocity in patients of Diabetic Neuropathy

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Original Article

Author Details : Saquib Alam, Kafil Akhtar*, Syed A Abbas, Sheelu S Siddiqui, Shagufta Moin

Volume : 6, Issue : 2, Year : 2020

Article Page : 96-100

https://doi.org/10.18231/j.ijn.2020.020

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Abstract

Introduction: Although vitamin D insufficiency is very prevalent in Type-2 diabetes mellitus, there are no studies to prove its role or association in diabetic peripheral neuropathy.
Aims and Objectives: We intend to highlight the relationship of Serum Vitamin D levels with Nerve Conduction Velocity in patients of Diabetic Peripheral Neuropathy.
Material and Methods: 52 patients of diabetic neuropathy were assessed for sensory and motor nerve conduction velocity along with serum Vitamin D levels estimation and the results were statistically
analyzed.
Results: Tingling was the most common symptom, seen in 31.1% cases. The numbers of nerve involvement increased with the duration of diabetes mellitus. Majority of the patients showed decrease in SNCV and MNCV in more than three nerves,17(32.69%) and 15(28.84%) cases. 14(87.5%) vitamin D deficient patients had HbA1c levels >11.5. Vitamin D deficiency was more pronounced than insufficiency as the HbA1c levels got increased. The vitamin D deficiency increased in proportion to the duration of disease, with maximum number of vitamin D deficient patients in the disease duration of 11-15 years followed by vitamin D deficient patients with duration of disease>15 years. 36(69.2%) of the diabetic patients were deficient in vitamin D, followed by vitamin D insufficiency in 14(26.9%) (p value<0 value=0.314). > Conclusions: Nerve conduction velocities and vitamin D deficiency might be independently associated with diabetic peripheral neuropathy, so these investigative parameters could be used as an independent marker to assess the severity of the neuropathy.

Keywords: Diabetes, Peripheral Neuropathy, Nerve Conduction Velocity, Vitamin D.

How to cite : Alam S, Akhtar K, Abbas S A, Siddiqui S S, Moin S, Relationship of Serum Vitamin D levels with Nerve Conduction Velocity in patients of Diabetic Neuropathy. IP Indian J Neurosci 2020;6(2):96-100

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