Mechanism and biomarkers for neurodegenerative diseases: A systematic review

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Original Article

Author Details : Nandini S*, Narayan Sah Sonar, Hemalatha S, N C Nagalakshmi, Harshita Arun Pardhe

Volume : 6, Issue : 1, Year : 2020

Article Page : 14-19

https://doi.org/10.18231/j.ijn.2020.003

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Abstract

Neurodegenerative disease such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Multiple sclerosis
(MS), Huntington’s disease (HD) are characterized by progressive loss of cognitive function, dementia
and problems with movement. Neuronal loss is associated with extra and intercellular accumulation of
misfolding proteins, oxidative stress, free radical formation, mitochondrial dysfunction, disruption of
neuronal golgi apparatus, impaired bioenergetics, dysfunction of neurotrophins.
Biomarkers that might aid in the diagnosis of these devastating and globally important disease are urgently
sought and required. Therefore, range of biomarkers are explained for neurodegenerative disease.

Keywords: Neurodegeneration, Alzheimer’s disease, Parkinson’s disease, Biomarkers.

How to cite : Nandini S, Sonar N S, Hemalatha S, Nagalakshmi N C, Pardhe H A, Mechanism and biomarkers for neurodegenerative diseases: A systematic review. IP Indian J Neurosci 2020;6(1):14-19

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